Related Experiment Video

Updated: Sep 25, 2025

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.0K

Circulating microRNA-27a and -133a are negatively associated with incident hypertension: a five-year longitudinal

Koji Suzuki1, Hiroya Yamada2, Ryosuke Fujii1

  • 1Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|April 25, 2022
PubMed
Abstract

Insights

Lower levels of circulating microRNAs (miR-27a and miR-133a) predict hypertension development in Japanese adults. These microRNAs may serve as biomarkers for hypertension prediction and prevention.

Area of Science:

  • Biomarkers
  • Hypertension Research
  • MicroRNA Biology

Background:

  • Cross-sectional studies suggest associations between circulating microRNA levels and hypertension.
  • Prospective studies evaluating microRNAs in relation to hypertension development in general populations are lacking.
  • Inflammatory and oxidative stress-responsive microRNAs are implicated in blood pressure regulation.

Purpose of the Study:

  • To investigate the impact of circulating inflammatory- and oxidative stress-responsive microRNAs on blood pressure changes.
  • To assess the predictive value of specific microRNAs for the development of hypertension in normotensive individuals.

Main Methods:

  • Prospective cohort study involving 84 normotensive Japanese participants examined in 2012 and 2017.
  • Serum microRNA (miR-21, miR-27a, miR-133a) levels were quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR).
  • Logistic regression analysis was employed to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for incident hypertension.

Main Results:

  • Lower serum levels of miR-27a and miR-133a were observed in participants who developed hypertension compared to those who remained normotensive.
  • A 1-unit decrease in serum miR-27a and miR-133a was associated with adjusted odds ratios of 0.84 (0.72-0.96) and 0.75 (0.58-0.91) for incident hypertension, respectively.
  • Individuals with high serum miR-27a and miR-133a levels exhibited significantly lower odds of developing hypertension compared to those with low levels.

Conclusions:

  • Circulating miR-27a and miR-133a are identified as potential biomarkers for predicting hypertension.
  • These microRNAs may play a role in the prevention strategies for hypertension.
  • The findings support the utility of miR-27a and miR-133a in early hypertension detection.
Keywords:
Blood pressureepigeneticshypertensionlongitudinal studymiRNA-133amiRNA-27amicroRNA

More Related Videos

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.6K
Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

2.4K

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.1K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
67
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
5.2K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
121
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
938
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.9K