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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
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Infectious mononucleosis - should we routinely assess liver function in acute presentation and follow up?
L Simpson1, E Sutherland1, D Wilkinson2
1Department of ENT, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
The Journal of Laryngology and Otology
|April 25, 2022
Summary
Serial liver function tests are unnecessary for adults with infectious mononucleosis and abnormal liver function tests. Most patients recover without complications, indicating routine follow-up is not required.
Area of Science:
- Hepatology
- Infectious Diseases
- Otolaryngology
Background:
- Infectious mononucleosis commonly presents to ENT departments.
- Abnormal liver function tests are frequent in infectious mononucleosis.
- Current follow-up guidelines for liver function are lacking.
Purpose of the Study:
- To assess the clinical utility of liver function tests (LFTs) in infectious mononucleosis.
- To evaluate the role of abdominal ultrasound in managing infectious mononucleosis.
- To determine the necessity of serial LFT monitoring post-discharge.
Main Methods:
- Retrospective study design.
- Inclusion of adult patients admitted with infectious mononucleosis over five years.
- Analysis of LFT results and abdominal ultrasound findings.
Main Results:
- Eighty percent of 153 patients exhibited abnormal LFTs at presentation.
- Median LFT resolution time was 32 days, with a maximum of 10 months.
- Abdominal ultrasounds in six patients revealed normal liver and biliary trees; no sequelae were observed.
Conclusions:
- Serial LFT assessment is not indicated for immunocompetent adults with infectious mononucleosis.
- Routine monitoring of liver function in these patients is unnecessary.
- Abdominal ultrasound did not reveal significant findings in the studied cohort.
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