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Related Experiment Video

Updated: Sep 25, 2025

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Subacute thyroiditis presenting as a painful suspicious thyroid nodule.

Wanling Zeng1, Sophie Tan2, Thomas Frederick James King1

  • 1Department of Endocrinology, Changi General Hospital, Singapore, Singapore.

Endocrinology, Diabetes & Metabolism Case Reports
|April 25, 2022
PubMed
Summary

Subacute thyroiditis can mimic suspicious thyroid nodules, presenting as painful lesions. Early recognition and symptomatic treatment lead to resolution of these thyroid lesions.

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Last Updated: Sep 25, 2025

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Area of Science:

  • Endocrinology
  • Pathology

Background:

  • Subacute thyroiditis can present atypically, lacking pain, normal erythrocyte sedimentation rate (ESR), or hyperthyroidism.
  • Ultrasound findings in subacute thyroiditis may resemble malignancy, showing focal or multifocal lesions with heterogeneous echogenicity.

Purpose of the Study:

  • To highlight a case of subacute thyroiditis presenting as painful thyroid nodules.
  • To emphasize the importance of recognizing subacute thyroiditis's potential to mimic suspicious thyroid nodules on ultrasound.

Main Methods:

  • Case report of a 40-year-old female with painful thyroid nodules.
  • Evaluation included thyroid ultrasound and fine-needle aspiration (FNA).
  • Diagnosis confirmed by clinical symptoms, biochemical markers, ESR, and thyroid scintigraphy.

Main Results:

  • Initial fine-needle aspiration (FNA) suggested a follicular lesion of undetermined significance (FLUS/AUS, Bethesda III).
  • The patient was diagnosed with subacute thyroiditis based on clinical and biochemical findings.
  • Thyroid lesions resolved with symptomatic treatment.

Conclusions:

  • Subacute thyroiditis can present with painful nodules and ultrasound features mimicking suspicious thyroid nodules.
  • Recognition of these atypical presentations is crucial for appropriate management.
  • Thyroid lesions associated with subacute thyroiditis can resolve with treatment.