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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Challenges in the screening and treatment of latent multidrug-resistant tuberculosis infection
Guofang Deng1, Peize Zhang1, Hongzhou Lu1
1Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen, China, The National Clinical Research Center for Infectious Diseases, Shenzhen, China.
Abstract:
Individuals in close contact with multidrug-resistant tuberculosis (MDR-TB) patients are subject to an elevated risk of infection, and may develop latent MDR-TB infection. Numerous studies have described latent tuberculosis infection (LTBI) as a reservoir of new TB disease. The screening and treatment of latent MDR-TB infection are challenging. Hereby, we reviewed the epidemiology, current management and prevention approach of LTBI in MDR-TB close contacts, to provide additional information for future research direction and policy design formulation to reduce the LTBI reservoir.
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