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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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A human coronavirus OC43-derived polypeptide causes neuropathic pain

Veronica I Shubayev1,2, Jennifer Dolkas1,2, Glaucilene Ferreira Catroli1,2

  • 1Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.

EMBO Reports
|April 25, 2022
PubMed
Summary

Human coronavirus OC43 (HCoV-OC43) infection may cause neuropathic pain through molecular mimicry. A viral peptide mimics myelin basic protein (MBP), leading to hypersensitivity and altered spinal cord gene expression.

Keywords:
Na+/K+-transporting ATPasecoronavirusmolecular mimicrymyelin basic proteinneuropathic pain

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