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Is type 2 diabetes mellitus another intercellular junction-related disorder?
Carla B Collares-Buzato1, Carolina Pf Carvalho2
1Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, CEP 13083-970, Brazil.
Experimental Biology and Medicine (Maywood, N.J.)
|April 25, 2022
Summary
Intercellular junctions (IJs) may contribute to type 2 diabetes (T2D) development. This review explores how IJs impact pancreatic, intestinal, and kidney functions in T2D pathogenesis.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Cell Biology
Background:
- Type 2 diabetes (T2D) is a global epidemic characterized by hyperglycemia due to insulin defects.
- It is a multifactorial condition posing significant challenges to healthcare systems worldwide.
Purpose of the Study:
- To review experimental and clinical evidence linking intercellular junctions (IJs) to T2D pathogenesis.
- To explore the role of IJs in endocrine pancreas, intestinal barrier, and kidney dysfunction in T2D.
Main Methods:
- Literature review of experimental and clinical studies.
- Analysis of the impact of IJs on key organs involved in T2D.
Main Results:
- Evidence suggests IJs-mediated cell-cell contacts are implicated in T2D development.
- Dysfunction of IJs contributes to endocrine pancreas, intestinal barrier, and kidney issues.
Conclusions:
- Intercellular junctions represent a novel target for understanding and potentially treating T2D.
- Further research into IJs' role in T2D is warranted.
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