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Updated: Sep 25, 2025
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
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Recent Developments in Proniosomal Transdermal Drug Delivery: An Overview
Vidya Sabale1, Manjusha Charde1,2, Nitin Dumore2
1Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur - 440037, Maharashtra, India.
Current Drug Delivery
|April 25, 2022
Summary
Proniosomes offer a stable, effective alternative to traditional drug delivery systems, minimizing gastrointestinal irritation and improving transdermal application. These vesicular systems show promise for targeted delivery across various diseases and applications.
Area of Science:
- Pharmaceutics and Drug Delivery
- Materials Science
Background:
- Proniosomes are advanced vesicular carriers superior to niosomes and liposomes for transdermal drug delivery.
- Oral drug administration faces challenges like GIT irritation and first-pass metabolism, making alternative routes desirable.
Approach:
- This review explores the preparation, composition, and skin interaction of proniosomes.
- It highlights the role of nonionic surfactants and phospholipids in enhancing drug penetration.
- The review also discusses the advantages of gel formulations for drug delivery.
Key Points:
- Proniosomes effectively encapsulate both hydrophobic and hydrophilic drugs.
- Non-ionic surfactants and phospholipids in proniosomes enhance stratum corneum penetration.
- Gels offer superior drug solubility and patient compliance compared to ointments and creams.
Conclusions:
- Proniosomes represent a significant advancement in vesicular drug delivery systems.
- Future applications include targeted delivery for melanoma, brain disorders, and enhanced delivery of proteins, peptides, and genes.
- Proniosomes also hold potential in cosmetics and nutraceuticals.
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