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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Flavonoids as Sirtuin Modulators
Fatma Sezer Şenol Deniz1, Gökçen Eren2, Ilkay Erdogan Orhan1
1Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey.
Current Topics in Medicinal Chemistry
|April 25, 2022
Summary
Flavonoids, natural compounds found in plants, can modulate sirtuins (SIRTs), a protein family linked to aging and disease. This review highlights their interactions, particularly with SIRT1 and SIRT3.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Sirtuins (SIRTs) are NAD+-dependent deacetylases involved in crucial biological processes like aging, metabolism, and inflammation.
- Seven mammalian sirtuin genes (SIRT1-7) have been identified, with SIRT1 being the most extensively studied.
- Small molecules are effective modulators of sirtuin activity, offering therapeutic potential.
Purpose of the Study:
- To review the modulatory effects of flavonoids on sirtuins (SIRTs).
- To explore the mechanisms by which flavonoids interact with sirtuins.
- To identify key flavonoids and sirtuin targets based on existing literature.
Main Methods:
- Literature survey of studies published between 2006 and 2021.
- Analysis of research focusing on flavonoid-sirtuin interactions.
- Identification of frequently targeted sirtuin isoforms and prominent flavonoid modulators.
Main Results:
- Flavonoids frequently interact with SIRT1 and SIRT3, and to a lesser extent, SIRT6.
- Popular flavonoid derivatives like resveratrol, quercetin, and catechin show significant sirtuin modulation.
- The literature indicates a growing interest in flavonoids as natural sirtuin modulators.
Conclusions:
- Flavonoids represent a promising class of natural compounds for modulating sirtuin activity.
- Targeting SIRT1 and SIRT3 with specific flavonoids may offer therapeutic benefits for age-related diseases.
- Further research is warranted to elucidate the precise mechanisms of flavonoid-sirtuin interactions.
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