Related Experiment Video
Updated: Sep 25, 2025
07:56
Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
Published on: May 5, 2023
485
Blood hyperviscosity in acute and recent COVID-19 infection
Aleesha Shaik1, Qinzhong Chen1, Phyu Mar1
1Metabolism and Lipids Unit, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, USA.
Clinical Hemorheology and Microcirculation
|April 25, 2022
Summary
Whole blood viscosity (WBV) is significantly elevated in acute and early convalescent COVID-19 patients, suggesting hyperviscosity contributes to thrombotic risk. These findings highlight the need for thromboprophylaxis in these patients.
Area of Science:
- Hematology
- Cardiovascular Physiology
- Infectious Diseases
Background:
- Elevated estimated blood viscosity (EBV) in COVID-19 correlates with poor outcomes.
- EBV, derived from hematocrit and globulins, doesn't capture cellular or fibrinogen effects.
- Understanding whole blood viscosity (WBV) in COVID-19 is crucial for assessing thrombotic risk.
Purpose of the Study:
- To investigate alterations in whole blood viscosity (WBV) in patients with acute and recent COVID-19.
- To measure WBV at both high and low shear rates using in vitro blood samples.
- To compare WBV in acute COVID-19, early convalescent, late convalescent, and control groups.
Main Methods:
- Cross-sectional study of 58 participants (15 acute COVID-19, 32 convalescent, 11 controls).
- Whole blood viscosity (WBV) measured at high shear rate (HSR, 300 s-1) and low shear rate (LSR, 5 s-1).
- Scanning capillary viscometer used for WBV measurements.
Main Results:
- Acute and convalescent (<8 weeks) COVID-19 patients exhibited significantly higher WBV at both HSR and LSR compared to controls.
- WBV in acute and early convalescent (<8 weeks) groups was significantly higher than in late convalescent (>8 weeks) patients.
- No significant WBV difference was found between acute and early convalescent (<8 weeks) groups, nor between late convalescent (>8 weeks) and control groups.
Conclusions:
- Sustained hyperviscosity in acute and early convalescent COVID-19 patients may explain their elevated thrombotic risk.
- These findings underscore the importance of considering hyperviscosity in thromboprophylaxis strategies for COVID-19 patients.
- WBV measurements offer a more comprehensive assessment of blood rheology in COVID-19 than EBV.
More Related Videos
10:40Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
Published on: August 4, 2012
12.8K
08:44An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices
Published on: August 21, 2020
7.3K
Related Concept Videos
01:30Venous Thrombosis I: Introduction
49
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
49
02:45Blood Transfusion and Agglutination
11.3K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
11.3K
01:24Disorders of Hemostasis
1.3K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.3K
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
49
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
49
01:17Measurement of Blood Pressure
1.5K
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
1.5K
01:30Venous Thrombosis IV: Nursing Management
33
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
33