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Complete Genome Sequence of Stenotrophomonas maltophilia Podophage Pepon

Jin Lee1, Johnathan Lo1, James Clark1,2

  • 1Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.

Microbiology Resource Announcements
|April 25, 2022
PubMed

Insights

We sequenced the genome of Stenotrophomonas maltophilia podophage Pepon. This bacteriophage is closely related to the Ponderosa phage and offers insights into S. maltophilia infections.

Area of Science:

  • Microbiology
  • Virology
  • Genomics

Background:

  • Stenotrophomonas maltophilia is an opportunistic pathogen.
  • It frequently causes respiratory infections in immunocompromised individuals, notably cystic fibrosis patients.

Purpose of the Study:

  • To present the complete genome sequence of S. maltophilia podophage Pepon.
  • To establish the phylogenetic relationship of Pepon to other known bacteriophages.

Main Methods:

  • Whole-genome sequencing of podophage Pepon.
  • Bioinformatic analysis of the obtained genome sequence.
  • Comparative genomics with related bacteriophages.

Main Results:

  • The complete genome sequence of podophage Pepon was successfully determined.
  • Pepon was identified as a T7-like phage.
  • Phylogenetic analysis revealed Pepon is closely related to the Ponderosa phage.

Conclusions:

  • The genome sequence of Pepon provides valuable genetic information for studying S. maltophilia phages.
  • Understanding Pepon's genomic characteristics can aid in developing phage-based therapeutic strategies against S. maltophilia infections.

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