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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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Cutaneous angiosarcoma presenting as bilateral periorbital edema.

Benjamin A West¹, Paul M Hoesly², Philip E LeBoit³

¹Department of Ophthalmology, University of California at Davis, Sacramento, California, USA.

Orbit (Amsterdam, Netherlands)

|April 25, 2022

Summary

Cutaneous angiosarcoma, a rare cancer, can manifest as eyelid swelling. Early diagnosis of this lymphatic cancer is crucial for effective treatment and preventing metastasis.

Keywords:

Angiosarcoma cutaneous angiosarcoma masquerade syndrome periorbital edema

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Area of Science:

Oncology
Dermatology
Ophthalmology

Background:

Periorbital edema can stem from various causes, necessitating a broad differential diagnosis.
Cutaneous angiosarcoma is a rare malignancy of lymphatic endothelial cells, typically affecting sun-exposed skin.

Observation:

A 66-year-old man presented with chronic bilateral periorbital edema, yellowish hue, violaceous macules, and forehead contracture.
Symptoms began 3 months post-dental surgery; initial investigations and treatments for common causes were ineffective.

Findings:

Atypical lymphatic endothelial cells in punch biopsies confirmed cutaneous angiosarcoma.
The patient showed limited response to immunotherapy and transitioned to hospice care.

Implications:

Cutaneous angiosarcoma, though uncommon, should be considered in periorbital edema cases, especially when refractory to standard treatments.
Timely diagnosis and intervention are vital to mitigate intradermal spread and metastatic potential of this aggressive cancer.