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Updated: Sep 25, 2025

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Symptom Association for Gastroesophageal Reflux Disease by pH Monitoring After Peroral Endoscopic Myotomy
John M DeWitt1, William R Kessler1, John M Wo1
1Department of Gastroenterology and Hepatology, Indiana University Health Medical Center, Indianapolis, Indiana, USA.
Introduction:
There are limited data correlating symptoms with reflux episodes during pH studies after peroral endoscopic myotomy.
Methods:
Consecutive patients who underwent POEM followed up ≥6 months later by 48-hour ambulatory wireless pH testing off antisecretory therapy were identified. Reflux symptom association was defined as symptom association probability >95%.
Results:
The most frequent symptoms of heartburn (47.2%), cough (45.1%), and chest pain (39.6%) were associated with a positive reflux symptom association (symptom association probability >95%) in 20.9%, 17.1%, and 19.4%, respectively.
Discussion:
There is poor correlation between reported symptoms and esophageal acid exposure during pH testing after POEM.
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