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Updated: Sep 25, 2025

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue.

Mohammad Mir¹, Jiawen Chen¹, Meghan R Pinezich¹

¹Department of Biomedical Engineering, Stevens Institute of Technology.

Journal of Visualized Experiments : Jove

|April 25, 2022

Summary

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This study introduces an imaging-guided bioreactor for creating lab-grown airway tissues. This technology aids in decellularizing tissue and culturing new cells for regenerative medicine applications.

Area of Science:

Regenerative Medicine
Biotechnology
Tissue Engineering

Background:

Chronic lung diseases like COPD result from repeated airway tissue injury.
Regenerative medicine and bioreactor advancements enable the creation of functional lab-grown tissues.
These engineered tissues can be used for drug screening, disease modeling, and tissue replacement.

Purpose of the Study:

To describe a novel miniaturized bioreactor system for in vitro airway tissue engineering.
To demonstrate imaging-guided manipulation and culture of explanted rat tracheas.
To showcase the potential for generating functional airway tissue constructs.

Main Methods:

A miniaturized bioreactor was coupled with an imaging modality for in situ visualization.

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Last Updated: Sep 25, 2025

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

Procedure for Lung Engineering

Procedure for Lung Engineering

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Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

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Imaging guided the selective removal of endogenous cells from rat trachea.

Exogenous cells were delivered, distributed, and cultured on the decellularized matrix with optical monitoring.

Main Results:

The bioreactor enabled imaging-guided decellularization while preserving tissue matrix integrity.
Successful delivery, uniform distribution, and prolonged culture of exogenous cells were achieved.
In situ optical monitoring facilitated real-time assessment during the process.

Conclusions:

The developed imaging-guided bioreactor system shows promise for in vitro airway tissue generation.
This technology can facilitate the engineering of functional airway tissues for research and therapeutic applications.
Preservation of tissue ultrastructure and biochemical features is achievable during decellularization.