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Related Concept Videos

Mass Spectrometers01:16

Mass Spectrometers

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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Mass Analyzers: Overview01:13

Mass Analyzers: Overview

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The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
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Mass Spectrometry: Overview01:19

Mass Spectrometry: Overview

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Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass.  One common type of ionization, known as electrospray ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave...
6.2K
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

917
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
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A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS
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Portable particle mass spectrometer.

Chun-Jen Hsiao1, Abdil Özdemir2, Jung-Lee Lin1

  • 1Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan. harrylin@gate.sinica.edu.tw.

The Analyst
|April 25, 2022
PubMed
Summary
This summary is machine-generated.

A new portable mass spectrometer accurately quantifies airborne microparticles, crucial for determining air quality and assessing health risks from particulate matter (PM10). This technology enables online analysis of environmental samples.

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Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Instrument Development

Background:

  • Airborne particle pollutants pose significant risks to human health.
  • Particulate Matter 10 (PM10) concentration is a key indicator of air quality.

Purpose of the Study:

  • To develop and validate a portable quadrupole ion trap mass spectrometer (QIT-MS) for microparticle quantitation.
  • To enable online analysis and accurate mass determination of airborne particles.

Main Methods:

  • Development of a portable quadrupole ion trap mass spectrometer (QIT-MS).
  • Quantitation of microparticles and particulate standards using the QIT-MS.
  • Calibration using PM10-like reference materials for size and mass distribution analysis.
  • Determination of detection efficiencies for polystyrene particles.

Main Results:

  • The developed QIT-MS successfully performed online analysis of various microsized particles.
  • Accurate mass determination of disperse particles was achieved via histogram profiles.
  • The instrument demonstrated potential for quantitating different particles in unknown environmental samples.

Conclusions:

  • The portable QIT-MS is a viable tool for the online analysis and quantitation of airborne microparticles.
  • This instrument aids in air quality determination by providing accurate size and mass distribution data.
  • The technology shows promise for identifying and quantifying unknown particulate matter in environmental samples.