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Updated: Sep 25, 2025

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Percutaneous coronary intervention in insulin-treated diabetic patients: A meta-analysis
Background:
This meta-analysis of randomized controlled trials (RCTs) compared long-term adverse clinical outcomes of percutaneous coronary intervention (PCI) in insulin-treated diabetes mellitus (ITDM) and non-ITDM patients.
Methods:
This is a meta-analysis study. The PubMed and Embase databases were searched for articles on long-term adverse clinical outcomes of PCI in ITDM and non-ITDM patients. The risk ratios (RR) and 95% confidence intervals (CI) were calculated.
Results:
A total of 11 related RCTs involving 8853 DM patients were included. Compared with non-ITDM patients, ITDM patients had significantly higher all-cause mortality (ACM) (RR = 1.52, 95% CI: 1.25-1.85, pheterogeneity = .689, I2 = 0%), major adverse cardiac and cerebrovascular events (MACCE) (RR = 1.35, 95% CI: 1.18-1.55, pheterogeneity = .57, I2 = 0%), myocardial infarction (MI) (RR = 1.41, 95% CI: 1.16-1.72, pheterogeneity = .962, I2 = 0%), and stent thrombosis (ST) (RR = 1.75, 95% CI: 1.23-2.48, pheterogeneity = .159, I2 = 32.4%). No significant difference was found in the target lesion revascularization (TLR) and target vessel revascularization (TVR) between the ITDM and non-ITDM groups.
Conclusions:
The results showed that ITDM patients had significantly higher ACM, MACCE, MI, and ST, compared with non-ITDM patients.
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