Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The ventricular gradient and repolarization.

J A Abildskov

    Japanese Heart Journal
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    The ventricular gradient concept, reflecting ventricular repolarization, is now validated by electrotonic effects. Measuring QRST deflection area can predict arrhythmias by assessing repolarization disparity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A model of electrical conduction in cardiac tissue including fibroblasts.

    Annals of biomedical engineering·2009
    Same author

    Electrophysiological modeling of fibroblasts and their interaction with myocytes.

    Annals of biomedical engineering·2007
    Same author

    Mechanisms in T-wave alternans caused by intraventricular block.

    Journal of electrocardiology·2000
    Same author

    Simulated torsade de pointes--the role of conduction defects and mechanism of QRS rotation.

    Journal of electrocardiology·2000
    Same author

    Effects of heart rate on vulnerability to fibrillation in a computer model.

    Journal of electrocardiology·1997
    Same author

    Mechanisms in adrenergic dependent onset of torsades de pointes.

    Pacing and clinical electrophysiology : PACE·1997
    Same journal

    Cardiac wall motion abnormalities observed in a patient with transient hyperthyroidism.

    Japanese heart journal·2005
    Same journal

    A case of deep venous thrombosis with a double inferior vena cava effectively treated by suprarenal filter implantation.

    Japanese heart journal·2005
    Same journal

    Pulmonary and aortic valve endocarditis in an adult patient with silent patent ductus arteriosus.

    Japanese heart journal·2005
    Same journal

    A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings.

    Japanese heart journal·2005
    Same journal

    False-positive exercise test secondary to Wolff-Parkinson-White syndrome in the absence of manifest preexcitation and disappearance of ST depressions after accessory pathway ablation.

    Japanese heart journal·2005
    Same journal

    Reel syndrome and pulsatile liver in a patient with a two-chamber pacemaker.

    Japanese heart journal·2005
    See all related articles

    Area of Science:

    • Electrophysiology
    • Cardiology
    • Computational Biology

    Background:

    • The ventricular gradient concept by Wilson offered insights into ventricular repolarization and its electrocardiographic representation.
    • Historically, the validity of the ventricular gradient was debated due to the QRST deflection area's dependence on ventricular activation sequence.

    Purpose of the Study:

    • To re-evaluate the ventricular gradient concept in light of electrotonic effects on repolarization.
    • To explore the relationship between QRST deflection area, repolarization disparity, and arrhythmia vulnerability.
    • To assess the clinical utility of QRST area mapping for predicting arrhythmias.

    Main Methods:

    • Theoretical modeling and experimental evidence were used to investigate electrotonic effects on repolarization.

    Related Experiment Videos

  • Analysis of the QRST deflection area in relation to ventricular activation and repolarization sequences.
  • Mapping of QRST deflection areas to evaluate repolarization properties and their distribution.

    • Main Results:

    • Electrotonic effects on repolarization explain the previously observed dependence of QRST deflection area on ventricular activation sequence.
    • There is substantial theoretical and experimental support that QRST deflection area is contingent upon the disparity of ventricular repolarization.
    • Measurements of QRST area show promise in predicting arrhythmias due to the link between repolarization disparity and arrhythmia vulnerability.

    Conclusions:

    • The ventricular gradient concept is physiologically valid, with electrotonic effects accounting for its relationship with ventricular activation.
    • QRST deflection area is a reliable indicator of repolarization disparity, a key factor in arrhythmia development.
    • Mapping QRST deflection areas provides valuable information on repolarization distribution and disparity, aiding in arrhythmia prediction.