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Methylation of the HCBP6 promoter is associated with primary biliary cholangitis pathogenesis
Lili Gao1, Yijin Zhang1, Xuesong Gao1
1Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, No.8, Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Abstract:
Hepatitis C virus core-binding protein 6 (HCBP6), first characterized in our laboratory and also referred to as FUNDC2, is involved in lipid and glucose metabolism, platelet activation, and platelet survival. Here we demonstrate that hypermethylation of mitochondrial HCBP6 is linked Primary Biliary Cholangitis (PBC) pathogenesis. Serum and liver levels of HCBP6 in PBC patients were reduced in comparison with controls. Further research confirmed a correlation between CpG1 hypermethylation and HCBP6 levels. Taken together, our results reveal another new feature of HCBP6.
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