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Updated: Sep 25, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Offloading treatment in people with diabetic foot disease: A systematic scoping review on adherence to foot
Simona Racaru1, Layla Bolton Saghdaoui2, Jaya Roy Choudhury3
1Vascular Research Department, Charing Cross Hospital, Fulham Palace Road, Imperial College Healthcare NHS Trust, London, W6 7RF, UK; Diabetes Education Centre, 1st Floor, Mint Wing, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, W2 1NY, UK.
Background And Aims:
To identify measurement methods, proportions of adherent participants, factors affecting adherence, and concordance promoting interventions.
Methods:
A systematic scoping review was conducted by searching Medline, CINAHL, PubMed, EMBASE, and EMCARE databases.
Results:
Twenty-four trials were identified from 1001 citations. Only 25% of the included studies used objective methods to quantify adherence. The proportion of adherent participants (≥80% of daily steps/time) ranged from 28% to 60%. Psychosocial factors are the most common influencers of adherence. However, interventions for improving compliance are lacking.
Conclusion:
There is a need to accurately quantify and optimize adherence to foot offloading in people with diabetes.
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