Related Experiment Video
Updated: Sep 25, 2025
06:39
Real-Time Void Spot Assay
Published on: February 10, 2023
2.2K
The Urobiome and Its Role in Overactive Bladder
1Department of Urology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
International Neurourology Journal
|April 25, 2022
Summary
The urinary tract harbors a microbiome, previously thought sterile. This microbial community influences urinary tract health and diseases like overactive bladder.
Area of Science:
- Microbiology
- Urology
- Genomics
Background:
- The urinary tract was historically considered sterile, but advances in next-generation sequencing and metagenomic analysis have revealed a complex microbiome.
- This urinary tract microbiome is increasingly linked to various conditions, including urinary tract infections, genitourinary malignancies, and lower urinary tract symptoms.
- Microbial community composition varies based on sampling methods, site, culture techniques, and sex, with distinct patterns observed in men and women.
Purpose of the Study:
- To explore the role of the urinary tract microbiome in health and disease.
- To investigate the association between the urinary tract microbiome and lower urinary tract symptoms, particularly overactive bladder.
- To highlight the variability of the microbiome and its implications for disease states.
Main Methods:
- Metagenomic analysis using next-generation sequencing to identify microbial species in urine samples.
- Comparative analysis of microbiome characteristics across different patient groups (e.g., healthy individuals vs. those with lower urinary tract symptoms) and demographic factors (sex).
- Review of existing literature on the urinary tract microbiome and its association with genitourinary conditions.
Main Results:
- The urinary tract microbiome is not sterile and plays a role in various genitourinary conditions.
- Microbiome composition differs significantly between individuals with and without specific lower urinary tract symptoms, such as urgency and urge urinary incontinence.
- Lactobacillus species are predominantly found in women, while other microbial species are more common in men.
Conclusions:
- The urinary tract microbiome is a significant factor in urological health and disease.
- Understanding the urinary tract microbiome offers potential diagnostic and therapeutic targets for conditions like overactive bladder.
- Further research is needed to fully elucidate the microbiome's role in other lower urinary tract symptoms.
More Related Videos
06:01Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
Published on: October 6, 2022
1.6K
06:36A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
7.3K
Related Concept Videos
01:23Urinary Bladder
1.6K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.6K
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
233
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
233
01:26The Micturition Reflex
1.1K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
1.1K
01:24Physiology of Urine Formation
6.8K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
6.8K
01:25Urinary Tract Infection II: Pathophysiology
61
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
61
01:20Disorders of the Urinary System
534
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
534