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Migfilin: Cell Adhesion Effect and Comorbidities.

Baoyu Duan1, Ziyao Qin2, Xuefeng Gu1

  • 1Department of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, People's Republic of China.

Oncotargets and Therapy
|April 26, 2022
PubMed
Summary
This summary is machine-generated.

Migfilin is a key cell adhesion protein regulating cell movement and growth. Its interactions are crucial in diseases, suggesting Migfilin as a potential therapeutic target.

Keywords:
FilaminKindlinMig-2Migfilincell-extracellular matrix adhesionscell–cell adhesions

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell adhesion is vital for tissue integrity and function, involving interactions with the extracellular matrix (ECM).
  • Migfilin, a widely expressed adhesion protein, plays a significant role in cellular processes through its unique structural domains.
  • Its binding partners, including Kindlin-2 and VASP protein, are critical for its function.

Purpose of the Study:

  • To elucidate the functional contributions and pathogenesis associated with Migfilin.
  • To detail the structure of Migfilin and its direct binding targets.
  • To summarize the role of Migfilin and its partners in disease progression.

Main Methods:

  • Literature review focusing on Migfilin's structure, binding partners, and functional roles.
  • Analysis of Migfilin's involvement in cellular processes like adhesion, migration, and signal transduction.
  • Examination of Migfilin's role in various diseases and malignancies.

Main Results:

  • Migfilin's structure includes LIM domains and a proline-rich sequence, facilitating interactions with multiple binding partners.
  • It orchestrates actomyosin fiber dynamics, impacting cell morphogenetic movement, adhesion, proliferation, migration, invasion, differentiation, and signal transduction.
  • Migfilin and its partners are implicated in the pathogenesis and progression of various diseases and cancers.

Conclusions:

  • Migfilin is a crucial coordinator of diverse cellular processes.
  • Its involvement in disease pathogenesis highlights its significance.
  • Migfilin presents a promising therapeutic target for clinical applications against multiple diseases.