Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

Factors Affecting Drug Response: Overview

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...

Allergic Reactions

Allergic Reactions

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Allergic Diseases During Pregnancy: Reassuring Uncertainty.

The journal of allergy and clinical immunology. In practice·2026

Same author

Shared Decision-Making and Health-Related Quality of Life in Drug Allergy.

The journal of allergy and clinical immunology. In practice·2026

Same author

The Natural History of Chronic Lung Allograft Dysfunction in Single and Bilateral Orthotopic Lung Transplant Recipients.

Transplantation·2026

Same author

Iodinated Contrast Media and Anaphylaxis.

Immunology and allergy clinics of North America·2026

Same author

Safely subtracting sulfa allergy: It's time.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same author

Combination therapy with TNF inhibitors plus biologics targeting type 2 inflammatory conditions in patients with rheumatoid arthritis: a case series.

Rheumatology advances in practice·2026

Search research articles

Related Experiment Video

Updated: Sep 25, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Telemedicine in Drug Hypersensitivity.

Deva Wells¹, Katherine L DeNiro¹, Allison Ramsey²

¹Division of Dermatology, University of Washington, 1959 Northeast Pacific Street, Box 356524, Seattle, WA 98195, USA.

Immunology and Allergy Clinics of North America

|April 26, 2022

Summary

Telemedicine can help assess drug hypersensitivity reactions, including penicillin allergies and severe cutaneous adverse reactions. While not replacing all in-person visits, it aids in risk stratification and reduces unnecessary appointments.

Keywords:

Adverse drug reaction Drug allergy Electronic consult Penicillin allergy Severe cutaneous adverse reaction Telehealth Telemedicine

More Related Videos

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Related Experiment Videos

Last Updated: Sep 25, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

Clinical Medicine
Pharmacology
Health Informatics

Background:

Drug hypersensitivity reactions pose a significant clinical challenge.
Accurate diagnosis and risk stratification are crucial for patient management.
Traditional allergy evaluations can be resource-intensive.

Purpose of the Study:

To review the current applications of telemedicine in managing drug hypersensitivity reactions.
To explore the potential of telemedicine in risk-stratifying patients with drug allergies.
To assess the role of telemedicine and electronic consults in drug allergy evaluations.

Main Methods:

Literature review of telemedicine applications in drug hypersensitivity.
Analysis of telemedicine's utility in evaluating penicillin allergies.
Assessment of telemedicine's role in severe cutaneous adverse reactions (SCARs).

Main Results:

Telemedicine shows promise for risk-stratifying patients with drug hypersensitivity.
It is applicable for evaluating penicillin allergies and SCARs.
Telemedicine may reduce the need for some in-person assessments.

Conclusions:

Telemedicine is a valuable tool for initial risk stratification in drug hypersensitivity.
It complements, but does not fully replace, in-person evaluations and testing.
Electronic consults are emerging as effective adjuncts for drug allergy assessments.