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Updated: Sep 25, 2025
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Posttreatment Gene Scores Support Histologic and Endoscopic Response Thresholds in Eosinophilic Esophagitis
Melanie A Ruffner1,2, Cary C Cotton3, Evan S Dellon3
1Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Introduction:
The correlation between clinical and molecular treatment response thresholds in eosinophilic esophagitis (EoE) is not well understood.
Methods:
We evaluated posttreatment EoE diagnostic panel gene expression profiles across histologic and endoscopic thresholds (EREFS) in a prospective adult EoE cohort.
Results:
We observed a strong inverse correlation between posttreatment gene score and eosinophil count (R = -0.66; P < 0.001); biopsies with <15 eos/hpf had higher gene scores (≥425) vs those with ≥15 eos/hpf. Findings for EREFS were similar; EREFS ≤2 was associated with EoE diagnostic panel scores ≥395.
Discussion:
Molecular signatures support the use of posttreatment response thresholds <15 eos/hpf and EREFS ≤2 in clinical practice and trials.
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