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[Recent progress in ergothioneine biosynthesis: a review].

Qi Liu1, Yufeng Mao1, Xiaoping Liao1

  • 1Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|April 26, 2022
PubMed
Summary

Researchers are advancing ergothioneine (ET) biosynthesis by identifying key pathways and enzymes. This review focuses on developing high-yield strains for increased ET production in edible mushrooms.

Keywords:
biosynthesisergothioneinefermentation engineeringmetabolic engineeringnatural mushroom

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Area of Science:

  • Biochemistry
  • Biotechnology
  • Mycology

Background:

  • Ergothioneine (ET) is a vital cytoprotector with diverse applications in food, beverages, medicine, and cosmetics.
  • Biosynthesis is emerging as a preferred method for ergothioneine production.
  • Recent advancements focus on understanding ET's molecular mechanisms and enhancing its yield.

Purpose of the Study:

  • To review recent progress in ergothioneine biosynthesis.
  • To identify key pathways and enzymes involved in ergothioneine production.
  • To explore strategies for increasing ergothioneine yield through strain development and bioengineering.

Main Methods:

  • Literature review of recent research on ergothioneine biosynthesis.
  • Analysis of key pathways and enzyme identification in ergothioneine synthesis.
  • Evaluation of strain development for high-yield ergothioneine production in edible mushrooms.

Main Results:

  • Identification of crucial pathways and enzymes for ergothioneine biosynthesis.
  • Development of natural edible mushroom species and high-yield engineering strains.
  • Progress in understanding the molecular mechanisms governing ergothioneine production.

Conclusions:

  • Ergothioneine biosynthesis research is rapidly advancing.
  • Fermentation engineering, metabolic engineering, and synthetic biology hold significant potential for boosting ergothioneine yields.
  • Further research can optimize ergothioneine production for various industrial applications.