Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study.
Jaime Ramos-Cejudo1,2, Andrew D Johnson3,4, Alexa Beiser4,5,6
1Department of Psychiatry New York University (NYU) Grossman School of Medicine New York NY.
Journal of the American Heart Association
|April 26, 2022
Summary
Higher platelet aggregation response in middle age is linked to an increased risk of developing dementia, including Alzheimer's disease (AD), later in life. This finding highlights platelet function as a potential early indicator for dementia risk.
Area of Science:
- Neurology
- Cardiovascular Science
- Gerontology
Background:
- Vascular dysfunction precedes Alzheimer's disease (AD) pathology.
- Abnormal platelet activation is observed in AD patients.
- Platelet function may be an early biomarker for AD risk.
Purpose of the Study:
- To investigate the independent association between platelet function in middle age and the future risk of dementia.
- To explore platelet phenotypes as potential prognostic markers for dementia.
Main Methods:
- Longitudinal analysis of community-based Framingham Heart Study (FHS) cohorts.
- Evaluation of baseline platelet aggregation response using light transmission aggregometry.
- Statistical modeling including inverse probability weighted Cox proportional cause-specific hazards regression.
Main Results:
- Platelet aggregation response to adenosine diphosphate (ADP) was independently associated with increased dementia risk.
- This association was significant even after adjusting for demographic and clinical factors.
- Higher platelet response to ADP and epinephrine indicated a greater risk, second only to age and hypertension.
Conclusions:
- Elevated platelet response is associated with higher dementia risk in individuals not on antiplatelet therapy.
- Platelet function may play a crucial role in AD pathogenesis and progression.
- Platelet phenotypes may offer prognostic value for dementia risk stratification.
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