Two Cases of Pelvic Diffuse Large B-Cell Lymphoma.

Area of Science:

• Oncology
• Gynecologic Oncology
• Hematology

Background:

• Primary diffuse large B-cell lymphoma (DLBCL) of the pelvis is an uncommon extranodal presentation.
• This condition can be misdiagnosed as gynecological malignancy due to similar clinical presentations.
• Delayed diagnosis of DLBCL can negatively impact prognosis despite standardized curative treatments.

Purpose of the Study:

• To highlight the diagnostic challenges of extranodal pelvic DLBCL.
• To emphasize the importance of a multidisciplinary approach in managing these rare cases.
• To present case studies of patients initially suspected of gynecological malignancy but diagnosed with pelvic DLBCL.

Main Methods:

• Retrospective case review of two female patients.
• Clinical presentation analysis, including imaging and pathology.
• Review of diagnostic workup and treatment protocols.

Main Results:

• Both patients presented with pelvic masses, initially suspected as gynecological cancers.
• Final diagnosis confirmed diffuse large B-cell lymphoma of the pelvis in both cases.
• Patients were managed with appropriate lymphoma treatment protocols.

Conclusions:

• Extranodal pelvic DLBCL requires high clinical suspicion, especially when mimicking gynecological malignancies.
• A prompt and accurate diagnosis is essential for timely initiation of curative therapy.
• Multidisciplinary collaboration is key for optimal management of rare pelvic lymphomas.