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Updated: Sep 25, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Monoclonal gammopathies and kidney: a diagnostic challenge without any clues]
Giulia Schiavone1, Fausta Catapano1, Enza Ratto1
1IRCCS Azienda Ospedaliero-Universitaria di Bologna. U.O. Nefrologia, Dialisi, Ipertensione, Bologna, Italy.
Abstract:
Diagnosis of monoclonal gammopathy of renal significance (MGRS) with histopathologic features of proliferative GN with monoclonal immunoglobulin deposits (PGNMID) is a challenge for clinicians because of the absence of laboratory findings suggestive of glomerular involvement in paraproteinemia. Renal biopsy remains the gold standard for diagnosis of PGNMID because it is a monoclonal gammopathy with kidney damage often "without a detectable serum/urine clone". Through this case report, we want to focus on the complexity both in the diagnostic process and in monitoring the renal-hematological response to therapy.
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