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Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic

Johan Frostegård1

  • 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Expert Review of Clinical Immunology
|April 26, 2022
PubMed

Insights

Antibodies against phosphorylcholine (anti-PC) show protective effects against chronic inflammatory diseases like cardiovascular disease (CVD) and atherosclerosis. Boosting anti-PC levels may offer a new therapeutic strategy for these conditions.

Area of Science:

  • Immunology
  • Inflammation
  • Cardiovascular Disease

Background:

  • Chronic inflammatory diseases represent a significant health burden.
  • Phosphorylcholine (PC) acts as both a danger-associated molecular pattern (DAMP) and a pathogen-associated molecular pattern (PAMP).
  • Antibodies against PC (anti-PC), specifically IgM and IgG1, are linked to protection in inflammatory conditions, particularly cardiovascular disease (CVD) and atherosclerosis.

Purpose of the Study:

  • To explore the role of anti-PC in chronic inflammatory diseases.
  • To investigate the potential of anti-PC as a predictive marker and therapeutic target.

Main Methods:

  • Literature review of PubMed and existing knowledge on atherosclerosis, immunology, and inflammation.
  • Analysis of the dual role of PC as DAMP and PAMP.
  • Examination of studies on anti-PC levels and their association with disease outcomes.

Main Results:

  • PC-immunization has demonstrated amelioration of atherosclerosis in animal models.
  • Proposed mechanisms include anti-inflammatory effects, reduced oxidized LDL uptake, and promotion of regulatory T cells.
  • Low anti-PC levels may result from reduced exposure to microorganisms.

Conclusions:

  • Anti-PC antibodies are associated with protection in chronic inflammatory diseases, notably CVD and atherosclerosis.
  • Anti-PC has potential for improving the prediction of clinical outcomes.
  • Therapeutic strategies aimed at increasing anti-PC levels could be developed for novel treatments.
Abstract

Keywords:
Antibodiesatherosclerosisimmunityinflammationphosphorylcholine

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