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Updated: Sep 25, 2025

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts
Published on: May 16, 2021
CARDIAC PAPILLARY FIBROELASTOMA: A CASE WITH UNPRECEDENTED SPREAD
João Lopes Cardoso1, Carolina Saleiro2, Ana Botelho2
1Department of Cardiothoracic Surgery, Coimbra Hospital and University Centre, Coimbra, Portugal.
Introduction:
Papillary fibroelastomas (PFE) are a rare primary cardiac neoplasm, out of which multifocal PFE constitute a small minority of cases. These benign masses are commonly found on valvular surfaces, particularly the aortic valve.
Clinical Case:
We present a patient with a history of embolic stroke and intra-cardiac masses. Multimodal imaging revealed multiple nodules with extensive intra-cardiac distribution. All nodules were successfully removed without valve dysfunction.
Conclusion:
This is a unique case of multiple PFE involving intracardiac cavities as well as all valvular structures.

