Related Experiment Video
Updated: Sep 25, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate
Leanne K Archer1, Fiona M Frame1, Hannah F Walker1
1Cancer Research Unit, Department of Biology, University of York, Heslington, UK.
None:
This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH-1) and prostate cancer (PC3) cell lines resulted in decreased colony-forming ability, inhibition of cell migration and reduced cell viability due to cell cycle arrest, establishing ELF3 as a cell cycle regulator. Increased ELF3 expression in more advanced prostate tumours was shown by immunostaining of tissue microarrays and from analysis of gene expression and genetic alteration studies. This study indicates that ELF3 functions not only as a part of normal prostate epithelial growth but also as a potential oncogene in advanced prostate cancers.
More Related Videos
09:58Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
12:44Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
Published on: November 11, 2014
Related Concept Videos
Master Transcription Regulators
Negative Regulator Molecules
Maintenance of the ES Cell State
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Abnormal Proliferation
Mitogens and the Cell Cycle