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Updated: Sep 25, 2025
UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media
Published on: October 25, 2021
Size characterization of nanomaterials in environmental and biological matrices through non-electron microscopic
Hongxin Xie1, Xing Wei2, Jiating Zhao3
1Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, Liaoning, China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, & CAS-HKU Joint Laboratory of Metallomics on Health and Environment, & Beijing Metallomics Facility, & National Consortium for Excellence in Metallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Abstract:
Engineered nanomaterials (ENs) can enter the environment, and accumulate in food chains, thereby causing environmental and health problems. Size characterization of ENs is critical for further evaluating the interactions among ENs in biological and ecological systems. Although electron microscope is a powerful tool in obtaining the size information, it has limitations when studying nanomaterials in complex matrices. In this review, we summarized non-electron microscope-based techniques, including chromatography-based, mass spectrometry-based, synchrotron radiation- and neutron-based techniques for detecting the size of ENs in environmental and biological matrices. The advantages and disadvantages of these techniques were highlighted. The perspectives on size characterization of ENs in complex matrices were also presented.
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