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Related Experiment Video

Updated: Sep 25, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Dopamine-related polymorphisms and Affective Working Memory in aging.

Beth Fairfield1, Caterina Padulo2, Nicola Mammarella2

  • 1Department of Psychological, Health and Territorial Sciences, University of Chieti-Pescara, Italy; University of Naples Federico II, Naples, Italy.

Neurobiology of Learning and Memory
|April 26, 2022
PubMed
Summary

Dopamine (DA) gene variants and cognitive scores predict affective working memory. Performance was enhanced for positive words in short memory strings, showing a general affective benefit for longer strings, independent of genotype.

Keywords:
Affective informationCOMTD1 receptorD2 receptorMemoryOlder adults

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychology

Background:

  • Dopamine (DA) is crucial for executive functions, and its system dysfunction impairs working memory.
  • Genetic variations in the DA system can influence working memory performance.

Purpose of the Study:

  • To develop a predictive model for affective working memory.
  • To investigate how genetic variants in dopamine receptors (D1, D2) and COMT influence affective working memory encoding.

Main Methods:

  • Examined 155 older adults, analyzing genotype variants (DRD2, DRD1, COMT).
  • Utilized Mini-Mental State Exam and Geriatric Depression Scale scores.
  • Assessed affective working memory performance based on word valence and string length.

Main Results:

  • Genotype variants, cognitive scores (MMSE, GDS) significantly predicted affective working memory.
  • Participants recalled positive words better than negative/neutral words in short strings (3-4 words).
  • Longer strings (5-6 words) showed a general affective enhancement, irrespective of genotype.

Conclusions:

  • Affective working memory is influenced by a combination of genetic and cognitive factors.
  • Specific dopaminergic gene variants did not uniquely alter affective working memory performance in this cohort.
  • Findings highlight the complex interplay of dopamine system genetics and cognitive function in memory processing.