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[Antibiotic sensitivity of Pasteurella multocida and related bacteria (bacterial groups M5 and EF4). Studies of
Abstract:
We have been isolating Pasteurella multocida and similar germs increasingly during the last few years: due to the rabies coming back in Eastern France, more consultations have been held following animal bites; samples are then taken for a bacteriologic research. We have studied their sensitivity towards 30 antibiotics. The determination of the MIC was achieved through the agar dilution method on 34 Pasteurella multocida of human origin issued after bites and expectorations, 4 EF4 and 4 M5. The Pasteurella are very sensitive to: beta-lactam antibiotics (the lowest MIC were observed for ureido-penicillins, amino-benzylpenicillins and third generation cephalosporins), chloramphenicol, cyclines and quinolones. Fosfomycin colistin and aminoglycosides are also active but with higher MIC. The macrolides have got a slow or no activity at all. The M5 are susceptible to the same antibiotics as Pasteurella but with slightly higher concentrations. Regarding EF4, minor sensitivity or resistance to penicillin G, cephalothin and cefamandole can be pointed out.
Insights
Pasteurella multocida from animal bites show high sensitivity to beta-lactam antibiotics, quinolones, and tetracyclines. Macrolides demonstrate limited effectiveness against these bacteria.
Area of Science:
- Bacteriology and Infectious Diseases
- Antimicrobial Resistance
- Public Health Microbiology
Context:
- Resurgence of rabies in Eastern France has led to increased animal bite consultations and subsequent bacteriologic analysis.
- Growing need to understand the antimicrobial susceptibility patterns of Pasteurella multocida and related bacteria isolated from human infections.
- Evaluation of antibiotic efficacy is crucial for effective treatment of infections resulting from animal-related injuries.
Purpose:
- To determine the in vitro sensitivity of Pasteurella multocida, EF4, and M5 strains to a panel of 30 antibiotics.
- To identify antibiotics with the lowest Minimum Inhibitory Concentrations (MIC) for effective treatment of Pasteurella infections.
- To compare the susceptibility profiles of P. multocida, EF4, and M5 strains.
Summary:
- Agar dilution method determined MICs for 34 human-origin P. multocida strains (from bites/expectorations), 4 EF4, and 4 M5 strains.
- Pasteurella multocida demonstrated high sensitivity to beta-lactams (ureido-penicillins, amino-benzylpenicillins, 3rd gen cephalosporins), chloramphenicol, tetracyclines, and quinolones.
- Fosfomycin, colistin, and aminoglycosides showed activity but with higher MICs; macrolides were largely ineffective. EF4 strains showed some resistance to penicillin G and early cephalosporins.
Impact:
- Provides critical data for guiding antibiotic selection in treating Pasteurella multocida infections, particularly those related to animal bites.
- Highlights the effectiveness of specific antibiotic classes, aiding clinicians in empirical and targeted therapy decisions.
- Informs antimicrobial stewardship efforts and surveillance of resistance patterns in clinically relevant bacteria.