Related Experiment Video

Updated: Sep 25, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.7K

Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma

Sara Ahmadpour1, Tarannomsadat Taghavi2, Amirhossein Sheida3,4

  • 1Department of Biotechnology, Faculty of Chemistry, University of Kashan, Kashan, Iran.

Epigenomics
|April 27, 2022
PubMed

Insights

This review explores how non-coding RNAs, including microRNAs and long non-coding RNAs, contribute to treatment resistance in glioma. Understanding these mechanisms may lead to new therapeutic strategies for brain tumors.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioma is the most common malignant primary brain tumor.
  • Glioma invasion into surrounding brain tissue poses a significant challenge.
  • Treatment resistance to chemotherapy and radiotherapy remains a major obstacle in glioma management.

Purpose of the Study:

  • To review the role of non-coding RNAs in glioma treatment resistance.
  • To elucidate the mechanisms by which microRNAs and long non-coding RNAs influence resistance.
  • To identify potential therapeutic targets for overcoming glioma resistance.

Main Methods:

  • Literature review of studies on non-coding RNAs in glioma.
  • Analysis of pathways involving microRNAs and long non-coding RNAs.
  • Synthesis of current understanding of treatment resistance mechanisms.

Main Results:

  • Non-coding RNAs play a crucial role in glioma progression and treatment resistance.
  • Specific microRNAs and long non-coding RNAs modulate cellular responses to chemotherapy and radiotherapy.
  • These non-coding RNAs represent potential biomarkers and therapeutic targets.

Conclusions:

  • Non-coding RNAs are key regulators of glioma treatment resistance.
  • Targeting microRNAs and long non-coding RNAs offers promising therapeutic avenues.
  • Further research into non-coding RNA pathways is essential for advancing glioma treatment.
Keywords:
chemotherapygliomalong non-coding RNAsmicroRNAsradiotherapy

More Related Videos

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.5K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K