Mechanisms of immune regulation for acupuncture on chronic respiratory diseases

Chronic respiratory diseases (CRDs) are among the most common noncommunicable diseases globally, with high morbidity and mortality rates. Acupuncture, a treatment method derived from Traditional Chinese Medicine, has been shown to be effective at treating CRDs, with little risk of adverse effects. Scientific research on the mechanisms underlying the effects of acupuncture, especially, its immune regulatory function, has rapidly advanced in recent years. Herein, the diverse immune regulatory mechanisms underlying the beneficial effects of acupuncture are summarized from the perspectives of innate immunity, adaptive immunity, and neuroimmunity. A better understanding of these mechanisms will ultimately provide a scientific basis for the clinical use of acupuncture for the treatment of CRDs.