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Shared-cathode closed bipolar electrochemiluminescence cloth-based chip for multiplex detection.

Wei Lai1, Yi Liang1, Yan Su1

  • 1MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.

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Summary

This study introduces a low-cost, cloth-based electrochemiluminescence (ECL) chip for multiplex detection. The novel shared-cathode closed bipolar ECL (SC-CBP-ECL) chip enables simultaneous detection of multiple analytes, offering a cost-effective solution for medical diagnostics.

Keywords:
Cloth-based chipElectrochemiluminescenceMultiplex detectionShared-cathode bipolar electrode

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Area of Science:

  • Analytical Chemistry
  • Biosensors
  • Materials Science

Background:

  • Electrochemiluminescence (ECL) chips are vital for medical diagnostics but are often expensive and require large sample volumes.
  • Existing ECL chip fabrication methods can be complex and costly, limiting widespread adoption.

Purpose of the Study:

  • To develop a novel, low-cost, and sample-efficient ECL chip for multiplex detection.
  • To demonstrate the capability of the new chip for simultaneous detection of multiple analytes, including glucose.

Main Methods:

  • Fabrication of shared-cathode closed bipolar electrochemiluminescence (SC-CBP-ECL) chips using screen-printing techniques with carbon ink and wax.
  • Optimization of ECL detection conditions for simultaneous detection of glucose using dual ECL systems (Ru(bpy)32+ and luminol).
  • Validation of chip performance using human serum samples and comparison with a clinical method.

Main Results:

  • The SC-CBP-ECL chips were produced at a low cost ($0.03-0.05 each).
  • Successful simultaneous detection of glucose was achieved with wide linear ranges (0.05-1 mM and 0.05-10 mM) and low detection limits (0.0382 mM and 0.0422 mM).
  • The chips demonstrated good specificity, reproducibility, stability, and agreement with clinical methods for glucose detection in serum.
  • The chip successfully detected seven glucose samples simultaneously and showed potential for detecting three different targets (H2O2, glucose, and uric acid).

Conclusions:

  • The developed SC-CBP-ECL cloth-based chip offers a cost-effective and efficient platform for multiplex detection in medical diagnostics.
  • This technology represents a significant advancement in the application of fiber material-based closed bipolar electrodes combined with dual ECL systems.
  • The chip shows broad potential for various point-of-care applications requiring simultaneous analysis of multiple biomarkers.