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Published on: March 9, 2018
Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study
1Department of Electrocardiogram, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, China.
Insights
Human adenovirus type 7 (HAdV-7) and invasive pulmonary fungal infections (IPFIs) co-infection is increasing. Aspergillus is the most common fungus in severe HAdV-7 pneumonia with IPFIs, requiring early prediction in vulnerable children.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pulmonology
Background:
- Rising incidence of co-infection between human adenovirus type 7 (HAdV-7) and invasive pulmonary fungal infections (IPFIs).
- Need to understand clinical characteristics of severe HAdV-7 pneumonia complicated by IPFIs.
Purpose of the Study:
- To explore clinical characteristics of severe HAdV-7 pneumonia combined with IPFIs.
- To identify common fungal species and patient factors associated with co-infection.
Main Methods:
- Retrospective study of patients with confirmed HAdV-7 infection from 2018-2019.
- Comparison of clinical data between patients with and without IPFIs.
Main Results:
- 35 out of 143 patients had IPFIs co-infection.
- Aspergillus was the most common fungal species.
- IPFIs group showed higher rates of respiratory failure, heart failure, and hemophagocytic syndrome, with lower WBC, CD3+, and CD19+ lymphocyte counts.
Conclusions:
- Aspergillus is the predominant fungus in HAdV-7 pneumonia with IPFIs.
- Early prediction of IPFIs in pediatric severe HAdV-7 pneumonia is crucial for younger patients with prolonged illness, ICU admission, multi-system dysfunction, and reduced lymphocyte counts.
Background:
There has been a rapid increase in the number of human adenovirus type 7 (HAdV-7) and invasive pulmonary fungal infections (IPFIs) co-infection.
Methods:
In this study, we included patients with confirmed HAdV-7 infection during the period from 2018 to 2019 to explore clinical characteristics of severe HAdV-7 pneumonia combined with IPFIs.
Results:
Among the 143 patients, 35 cases were co-infected with IPFIs. Others were assigned to the control group (n Z 108). Patients wereprone to be complicated with respiratory failure, heart failure and hemophagocytic syndromein IPFIs group. Thirty-one species of fungi were detected in the IPFIs group, among whichAspergillus was the most common species. Compared to control group, patients had lowerlevels of WBC, CD3þ T lymphocyte counts and CD19þ B lymphocyte counts in IPFIs group.
Conclusion:
Aspergillus is the most common species in IPFIs combined with severe HAdV-7 pneumonia. For children with severe HAdV-7 pneumonia who are younger, have a long course of disease, and have been admitted to the ICU, we should predict the occurrence of IPFIs when there is multi-system dysfunction and the reduction of CD3+ T lymphocyte counts and CD19+ B lymphocyte counts in course of their disease.
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