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Targeting NAD+: is it a common strategy to delay heart aging?

Yang Yuan1, Bing Liang1, Xin-Lin Liu1

  • 1Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China.

Cell Death Discovery
|April 27, 2022
PubMed

Insights

Nicotinamide adenine dinucleotide (NAD+) plays a crucial role in delaying heart aging and preventing age-related heart diseases. However, metabolic changes and oxidative stress can affect NAD+ function, requiring personalized therapeutic strategies.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Biochemistry

Background:

  • Heart aging is a primary risk factor for coronary heart disease and heart failure, particularly after ischemia-reperfusion injury.
  • Nicotinamide adenine dinucleotide (NAD+) supplementation is explored for anti-aging benefits, but its specific role in cardiac aging requires comprehensive review.
  • Existing research on NAD+ signaling in cardiac aging is fragmented, necessitating a consolidated understanding.

Purpose of the Study:

  • To comprehensively review the role of NAD+ signaling in delaying heart aging.
  • To explore the influence of NAD+ supplementation on the aging heart.
  • To elucidate the relationship and cross-talks between NAD+ signaling and other cardiac aging pathways.
  • To discuss the therapeutic potential of targeting NAD+ for age-related heart diseases.

Main Methods:

  • Systematic review of current studies on NAD+ signaling and cardiac aging.
  • Analysis of NAD+ supplementation effects on the aging heart.
  • Investigation of interactions between NAD+ signaling and other relevant pathways.
  • Discussion of therapeutic strategies targeting NAD+.

Main Results:

  • NAD+ is vital for delaying heart aging processes.
  • Altered metabolism, oxidative stress, and calcium overload can impair NAD+ function in the aging heart.
  • NAD+ signaling pathways interact with other critical cardiac aging mechanisms.

Conclusions:

  • NAD+ plays a significant role in mitigating cardiac aging.
  • Therapeutic strategies targeting NAD+ show promise for preventing age-related heart diseases.
  • Consideration of individual cardiac physiopathology is essential for effective NAD+ supplementation.

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