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Targeting NAD+: is it a common strategy to delay heart aging?
Yang Yuan1, Bing Liang1, Xin-Lin Liu1
1Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China.
Cell Death Discovery
|April 27, 2022
Summary
Nicotinamide adenine dinucleotide (NAD+) plays a crucial role in delaying heart aging and preventing age-related heart diseases. However, metabolic changes and oxidative stress can affect NAD+ function, requiring personalized therapeutic strategies.
Area of Science:
- Cardiovascular Science
- Gerontology
- Biochemistry
Background:
- Heart aging is a primary risk factor for coronary heart disease and heart failure, particularly after ischemia-reperfusion injury.
- Nicotinamide adenine dinucleotide (NAD+) supplementation is explored for anti-aging benefits, but its specific role in cardiac aging requires comprehensive review.
- Existing research on NAD+ signaling in cardiac aging is fragmented, necessitating a consolidated understanding.
Purpose of the Study:
- To comprehensively review the role of NAD+ signaling in delaying heart aging.
- To explore the influence of NAD+ supplementation on the aging heart.
- To elucidate the relationship and cross-talks between NAD+ signaling and other cardiac aging pathways.
- To discuss the therapeutic potential of targeting NAD+ for age-related heart diseases.
Main Methods:
- Systematic review of current studies on NAD+ signaling and cardiac aging.
- Analysis of NAD+ supplementation effects on the aging heart.
- Investigation of interactions between NAD+ signaling and other relevant pathways.
- Discussion of therapeutic strategies targeting NAD+.
Main Results:
- NAD+ is vital for delaying heart aging processes.
- Altered metabolism, oxidative stress, and calcium overload can impair NAD+ function in the aging heart.
- NAD+ signaling pathways interact with other critical cardiac aging mechanisms.
Conclusions:
- NAD+ plays a significant role in mitigating cardiac aging.
- Therapeutic strategies targeting NAD+ show promise for preventing age-related heart diseases.
- Consideration of individual cardiac physiopathology is essential for effective NAD+ supplementation.
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