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Mediastinal "deep freeze"-transcarinal lymph node cryobiopsy.

Evgeni Gershman1,2, Alon Amram Ikan2,3, Barak Pertzov1,2

  • 1Pulmonary Division, Rabin Medical Center, Petah Tikva, Israel.

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Summary
This summary is machine-generated.

Transcarinal cryobiopsy using endobronchial ultrasound (EBUS) provides larger samples for molecular evaluation of mediastinal lymph nodes. This novel technique demonstrated high diagnostic yield and safety in a recent study.

Keywords:
cryoprobeendobronchial ultrasoundlymph nodetranscarinal

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Area of Science:

  • Pulmonology
  • Interventional Pulmonology
  • Oncology

Background:

  • Endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) has a diagnostic yield of 66%-89% for mediastinal lymph nodes.
  • Cytologic material from EBUS-TBNA is often insufficient for comprehensive molecular analysis.
  • Transcarinal cryobiopsy offers a novel approach for larger bronchoscopically obtained tissue samples.

Purpose of the Study:

  • To evaluate the efficacy and safety of transcarinal EBUS-guided lymph node cryobiopsy.
  • To assess the diagnostic yield of this novel cryobiopsy technique.

Main Methods:

  • Prospective interventional study enrolling patients referred for EBUS-TBNA.
  • Procedures utilized a 22G needle for tract creation and TBNA, followed by insertion of 1.1 mm or 1.7 mm cryoprobes into subcarinal lymph nodes.
  • EBUS-guided transcarinal cryobiopsy was performed using flexible cryoprobes.

Main Results:

  • Twenty-four patients (mean age 60.12 years, 2:1 male predominance) were enrolled.
  • Transcarinal cryobiopsy yielded a pathological diagnosis in 83.33% of cases (20/24).
  • No immediate or late complications were observed during or after the procedures.

Conclusions:

  • Transcarinal EBUS-guided lymph node cryobiopsy is an efficient procedure with a high diagnostic yield.
  • The technique is safe, with no complications reported in the study.
  • This method provides a valuable alternative for obtaining adequate tissue for molecular evaluation.