Papulonodular Mucinosis Associated With Subacute Lupus

Area of Science:

• Dermatology
• Rheumatology
• Pathology

Background:

• Papulonodular mucinosis is a rare finding in lupus erythematosus (LE).
• It is exceptionally associated with subacute cutaneous lupus erythematosus (SCLE).
• The etiology and pathogenesis of papulonodular mucinosis remain unclear.

Observation:

• A middle-aged woman presented with asymptomatic flesh-colored papules and nodules on her trunk and upper extremities.
• A biopsy of a nodule revealed dermal and hypodermal mucin deposition.
• Perivascular lymphocytic inflammation was noted on histopathology.

Findings:

• This case documents papulonodular mucinosis in association with subacute cutaneous lupus erythematosus (SCLE).
• Histopathological examination confirmed mucin deposition and inflammation.
• The patient's presentation adds to the limited literature on this rare association.

Implications:

• The proportion of patients with cutaneous lupus mucinosis progressing to systemic lupus is uncertain.
• Close monitoring for multisystem disease is recommended for patients with SCLE-associated mucinosis.
• Further research into the pathogenesis of this rare condition is warranted.