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Gold lung: recent developments in pathogenesis, diagnosis, and therapy.

R B Evans, D B Ettensohn, F Fawaz-Estrup

Seminars in Arthritis and Rheumatism

|February 1, 1987

Summary

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Gold lung is a hypersensitivity pneumonitis caused by gold compounds. Early recognition and treatment, including stopping gold therapy and using corticosteroids, are key for managing this condition.

Area of Science:

Pulmonary Medicine
Immunology

Background:

Gold-containing compounds have been used to treat rheumatoid arthritis.
Hypersensitivity pneumonitis can occur as a rare side effect of gold therapy.

Observation:

Gold lung presents with acute or subacute onset.
Chest imaging shows diffuse interstitial and/or alveolar patterns.
Bronchoalveolar lavage (BAL) reveals lymphocytes with an inverted helper/suppressor ratio.

Findings:

Diagnosis relies on clinical presentation, imaging, and BAL findings.
In vitro tests for gold hypersensitivity are often unreliable.
Response to gold withdrawal and corticosteroid therapy supports the diagnosis.

Implications:

Related Experiment Videos

Physicians should monitor patients for pulmonary symptoms during gold therapy.
Promptly withholding gold and initiating treatment can improve outcomes.
Distinguishing gold lung from rheumatoid lung is crucial for appropriate management.