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Related Experiment Video

Updated: Sep 25, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

Engineered probiotics.

Junheng Ma^1,2, Yuhong Lyu¹, Xin Liu³

¹Key Laboratory of Microbial Drugs Innovation and Transformation, Medical College, Yan'an University, Yan'an, 716000, Shaanxi, China.

Microbial Cell Factories

|April 28, 2022

Summary

Engineered probiotics, modified using gene editing, show promise for treating diseases like IBD and cancer. These genetically modified microorganisms offer new diagnostic and industrial production possibilities.

Keywords:

CRISPR Disease diagnosis and treatment Engineered probiotics Gene editing Genetic engineering Synthetic biology

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Last Updated: Sep 25, 2025

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Published on: April 7, 2023

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Area of Science:

Microbiology
Biotechnology
Genetic Engineering

Background:

Engineered probiotics are microorganisms modified via gene editing.
Advances in gene editing tools enhance the feasibility and diversity of probiotic engineering.
Recent progress highlights the potential of engineered probiotics for human benefit.

Purpose of the Study:

To review the theoretical basis of gene editing technology.
To focus on recent research in engineered probiotics for various diseases.
To explore applications in disease diagnosis and industrial production.

Main Methods:

Review of gene editing technology principles.
Analysis of current research on engineered probiotics.
Synthesis of findings related to therapeutic and industrial applications.

Main Results:

Gene editing enables diverse modifications of probiotics.
Engineered probiotics show potential in treating inflammatory bowel disease, bacterial infections, tumors, and metabolic diseases.
Applications extend to disease diagnosis and industrial processes.

Conclusions:

Gene editing significantly advances engineered probiotics.
Engineered probiotics hold promise for treating intractable diseases.
This field offers new avenues for diagnostics and industrial biotechnology.