Discovery of phenytoin.

Area of Science:

• Pharmacology
• Neurology

Background:

• Early 1920s structure/hypnotic activity studies with barbiturates and hydantoins.
• Development of anticonvulsant (AC) assay techniques in animal models.

Observation:

• Phenytoin was identified as a compound with AC properties in animal studies.
• Clinical efficacy of phenytoin was established in 1937.

Findings:

• Phenytoin demonstrated anticonvulsant properties.
• Successful clinical trials led to its establishment as an effective treatment.

Implications:

• Paved the way for phenytoin's marketing as Dilantin sodium capsules.
• Significant advancement in epilepsy treatment and drug development.