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Clinical practice guideline recommendations for pediatric injury care: protocol for a systematic review
Lynne Moore1,2, Gabrielle Freire3, Anis Ben Abdeljelil2
1Department of Social and Preventive Medicine, Faculté de médecine, Université Laval, Quebec City, Quebec, Canada lynne.moore@fmed.ulaval.ca.
Insights
This systematic review appraises clinical practice guidelines (CPGs) for paediatric injury care to address quality deficiencies in paediatric trauma. Findings will inform evidence-based care improvements for children experiencing injuries.
Area of Science:
- Pediatric Trauma Care
- Clinical Practice Guidelines
- Systematic Review
Background:
- Significant deficiencies exist in the quality of care for pediatric trauma patients.
- Lack of adherence to evidence-based recommendations may stem from guideline knowledge gaps or quality concerns.
Purpose of the Study:
- To systematically review and appraise clinical practice guideline (CPG) recommendations for pediatric injury care.
- To identify and evaluate the quality of existing CPGs to improve care for injured children.
Main Methods:
- Comprehensive literature search across multiple databases and organizational websites.
- Independent screening, data extraction, and quality appraisal of CPGs using AGREE II and AGREE Recommendations Excellence.
- Synthesis of evidence using GRADE Evidence-to-Decision framework.
Main Results:
- Systematic review and quality appraisal of CPG recommendations for pediatric injury care.
- Identification of potential heterogeneity and quality issues in current guidelines.
- Synthesis of evidence to inform best practices in pediatric trauma management.
Conclusions:
- The quality of care for pediatric trauma patients requires improvement.
- Systematic appraisal of CPGs is crucial for enhancing evidence-based pediatric injury care.
- Findings will guide the development and implementation of higher-quality clinical practice guidelines.
Introduction:
Evidence suggests the presence of deficiencies in the quality of care provided to up to half of all paediatric trauma patients in Canada, the USA and Australia. Lack of adherence to evidence-based recommendations may be driven by lack of knowledge of clinical practice guidelines (CPGs), heterogeneity in recommendations or concerns about their quality. We aim to systematically review CPG recommendations for paediatric injury care and appraise their quality.
Methods And Analysis:
We will identify CPG recommendations through a comprehensive search strategy including Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, Cochrane library, Web of Science, ClinicalTrials and websites of organisations publishing recommendations on paediatric injury care. We will consider CPGs including at least one recommendation targeting paediatric injury populations on any diagnostic or therapeutic intervention from the acute phase of care with any comparator developed in high-income countries in the last 15 years (January 2007 to a maximum of 6 months prior to submission). Pairs of reviewers will independently screen titles, abstracts and full text of eligible articles, extract data and evaluate the quality of CPGs and their recommendations using Appraisal of Guidelines Research and Evaluation (AGREE) II and AGREE Recommendations Excellence instruments, respectively. We will synthesise evidence on recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence-to-Decision framework and present results within a recommendations matrix.
Ethics And Dissemination:
Ethics approval is not a requirement as this study is based on available published data. The results of this systematic review will be published in a peer-reviewed journal, presented at international scientific meetings and distributed to healthcare providers.
Prospero Registration Number:
International Prospective Register of Systematic Reviews (CRD42021226934).
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