Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatosensation01:33

Somatosensation

38.8K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
38.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Response Selectivity Changes in the Primary Visual and Parietal Cortex during Visual Discrimination Learning.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Discretized representations in V1 predict suboptimal orientation discrimination.

Nature communications·2025
Same author

Shifts in attention drive context-dependent subspace encoding in anterior cingulate cortex in mice during decision making.

Nature communications·2024
Same author

Continuous multiplexed population representations of task context in the mouse primary visual cortex.

Nature communications·2023
Same author

Estimating How Sounds Modulate Orientation Representation in the Primary Visual Cortex Using Shallow Neural Networks.

Frontiers in systems neuroscience·2022
Same author

Neuropilin 2/Plexin-A3 Receptors Regulate the Functional Connectivity and the Excitability in the Layers 4 and 5 of the Cerebral Cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2022
Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Representations of subsecond duration-based timing by complex spike synchrony in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The extended language network: Language-responsive brain areas whose contributions to language remain to be discovered.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Cortical and thalamic afferent connectomes distinguish ACC subregions of the macaque brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Related Experiment Video

Updated: Sep 25, 2025

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

10.2K

Dynamic Distortion of Orientation Representation after Learning in the Mouse Primary Visual Cortex.

Julien Corbo1, John P McClure1,2, O Batuhan Erkat1,2

  • 1Center for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, New Jersey 07102.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 28, 2022
PubMed
Summary
This summary is machine-generated.

Mice learning an orientation discrimination task showed improved visual cortex representations of relevant stimuli. This involved suppressing neighboring orientations, enhancing accuracy and promoting generalization of learned cues.

Keywords:
calcium imaginglearningmouseorientationrepresentationvisual cortex

More Related Videos

Video-oculography in Mice
09:43

Video-oculography in Mice

Published on: July 19, 2012

24.0K
Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks
08:42

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks

Published on: August 4, 2018

14.3K

Related Experiment Videos

Last Updated: Sep 25, 2025

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

10.2K
Video-oculography in Mice
09:43

Video-oculography in Mice

Published on: July 19, 2012

24.0K
Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks
08:42

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks

Published on: August 4, 2018

14.3K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Sensory Processing

Background:

  • Learning enables behavioral adaptation via neuronal processing adjustments.
  • Sensory cortical neuron activity changes with task-relevant stimuli during learning.
  • The precise nature and computational benefits of these neural modifications remain under investigation.

Purpose of the Study:

  • To investigate how learning an orientation discrimination task modifies neuronal representations of cue orientations in the primary visual cortex (V1).
  • To understand the computational advantages conferred by these learned modifications in visual processing.

Main Methods:

  • Comparing neuronal activity evoked by task stimuli in naive versus trained mice (male and female).
  • Analyzing orientation discrimination task performance and its correlation with neural representation changes.
  • Investigating the role of neuronal suppression in V1 orientation representation.

Main Results:

  • Trained mice exhibited more accurate and stable representations of rewarded and non-rewarded cue orientations in V1.
  • A distortion of the V1 orientation representation space occurred, generalizing flanking stimuli to task-relevant orientations.
  • This distortion was context-dependent, absent during passive viewing and enhanced during high-performance behavioral sessions.
  • Suppression of activity in neurons tuned to neighboring orientations supported these V1 representation modifications.

Conclusions:

  • Visual processing in V1 dynamically adapts to enhance the reliability of learned cue representations.
  • Learned modifications in V1 favor generalization within the task-relevant computational space.
  • A suppression mechanism improves the representation of task stimuli orientations in V1, leading to generalization.