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Updated: Aug 12, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
Increase in Bone Mass Before Onset of Type 1 Diabetes Mellitus in Rats
Lyubomir Haralambiev1,2, Andreas Nitsch3, Cornelius S Fischer4
1Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany; Lyubomir.haralambiev@uni-greifswald.de.
Background/Aim:
The typical insulin deficiency in type 1 diabetes mellitus has general effects on metabolism and also affects bone quality.
Materials And Methods:
Two diabetic rat lines (BB/OK; BB.6KWR) and two non-diabetic rat strains (KWR and BB.14+18KWR), as control group, were included in the study. Bone mineral density, bone mineral content and body structure measurements were performed. The measurements took place before the onset of diabetes mellitus Results: A comparison of the groups showed increased bone density values of the diabetic rats in relation to the control groups. A new finding of increased bone density in the diabetic rats occurs.
Conclusion:
Diabetic rats showed no osteoporotic bone metabolism before the onset of clinically relevant type 1 diabetes mellitus, but rather increased bone metabolic activity.
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