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Related Experiment Video

Updated: Sep 25, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
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Outcomes of Interventions for Angiosarcoma.

Qi Yan1, Roman A Fernandez2, Maryam Elmi1,3

  • 1Department of Surgery, Long School of Medicine University of Texas Health at San Antonio, San Antonio, TX, United States.

Frontiers in Surgery
|April 28, 2022
PubMed
Summary
This summary is machine-generated.

Angiosarcoma, a rare vascular cancer, has a low incidence and poor survival rates. Combining surgery with chemotherapy or radiation therapy significantly improves long-term survival compared to surgery alone.

Keywords:
angiosarcomainterventionoutcomesregistrysurvival

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Last Updated: Sep 25, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

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Area of Science:

  • Oncology
  • Vascular Biology
  • Epidemiology

Background:

  • Angiosarcoma is a rare malignant vascular tumor with poorly described management and outcomes.
  • Understanding its incidence, demographics, and treatment effectiveness is crucial for improving patient care.

Purpose of the Study:

  • To report the incidence, patient demographics, and outcomes of angiosarcoma using national data.
  • To evaluate the survival benefits of multimodal therapy versus surgery alone.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) database for patient data (1975-2016).
  • Employed Inverse Probability Treatment Weights (IPTW) and Cox regression to analyze survival outcomes.
  • Compared outcomes for patients receiving surgery with or without chemo/radiation versus those not operated on.

Main Results:

  • Identified 5,135 angiosarcoma patients; incidence rate was 1-4%.
  • High-grade tumors were common, with an overall 5-year survival of 26.7%.
  • Multimodal therapy showed improved survival after 25 months compared to surgery alone, while surgery alone showed worse survival than no operation initially.

Conclusions:

  • Angiosarcoma incidence is low, and long-term survival remains poor.
  • Multimodal therapy (chemo/radiation with surgery) offers significant long-term survival benefits over surgery alone.