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Protocol to analyze the bacterial pangenome using PAN2HGENE software.

Pablo Henrique Caracciolo Gomes de Sá1, Jorianne Thyeska Castro Alves2, Adonney Allan de Oliveira Veras3

  • 1Federal Rural University of Amazonia Campus Tomé-Açu (UFRA), Pará, Brazil.

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|April 28, 2022
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Summary

The PAN2HGENE computational tool identifies missing gene products in prokaryotic genomes and performs automated comparative analyses. This user-friendly software simplifies genomic research without complex command lines.

Keywords:
BioinformaticsGeneticsGenomicsMicrobiologySequence analysis

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Prokaryotic genome analysis is crucial for understanding microbial life.
  • Identifying gene products and performing comparative genomics are essential tasks.
  • Existing tools may require complex command-line expertise.

Purpose of the Study:

  • To introduce PAN2HGENE, a novel computational tool for prokaryotic genome analysis.
  • To provide a user-friendly interface for identifying absent gene products.
  • To enable automated comparative genomic analysis for complete and draft genomes.

Main Methods:

  • Development of the PAN2HGENE computational tool.
  • Implementation of algorithms for identifying absent gene products.
  • Integration of comparative analysis features for prokaryotic genomes.
  • Design of a simple and intuitive graphical user interface (GUI).

Main Results:

  • PAN2HGENE successfully identifies gene products missing from prokaryotic genome sequences.
  • The tool facilitates automated comparative analysis of both complete and draft genomes.
  • The GUI simplifies complex genomic analyses, reducing the need for command-line proficiency.

Conclusions:

  • PAN2HGENE offers an accessible and efficient solution for key prokaryotic genome analysis tasks.
  • The tool democratizes genomic research by providing an intuitive GUI.
  • PAN2HGENE supports both gene product identification and comparative genomics.