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Updated: Sep 25, 2025

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
Published on: January 19, 2020
Recent developments in the kinetics of ruptures of giant vesicles under constant tension
Mohammad Abu Sayem Karal1, Md Kabir Ahamed1, Marzuk Ahmed1
1Department of Physics, Bangladesh University of Engineering and Technology Dhaka-1000 Bangladesh asayem221@phy.buet.ac.bd +880-2-58613046 +880-2-9665613.
Abstract:
External tension in membranes plays a vital role in numerous physiological and physicochemical phenomena. In this review, recent developments in the constant electric- and mechanical-tension-induced rupture of giant unilamellar vesicles (GUVs) are considered. We summarize the results relating to the kinetics of GUV rupture as a function of membrane surface charge, ions in the bathing solution, lipid composition, cholesterol content in the membrane, and osmotic pressure. The mechanical stability and line tension of the membrane under these conditions are discussed. The membrane tension due to osmotic pressure and the critical tension of rupture for various membrane compositions are also discussed. The results and their analysis provide a biophysical description of the kinetics of rupture, along with insight into biological processes. Future directions and possible developments in this research area are included.
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