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Outcomes of SARS-CoV-2 infection in patients with celiac disease: a multicenter research network study
Yousaf Bashir Hadi1, Amir Humza Sohail2, Dhairya A Lakhani3
1Department of Medicine, West Virginia University, Morgantown (Yousaf Bashir Hadi, Syeda Fatima Naqvi, Justin T. Kupec, Asad Pervez).
Background:
Celiac disease (CD) is associated with an increased risk for respiratory infections and severe outcomes. No data have been reported in the scientific literature regarding the outcomes of COVID-19 in this population. The aim of this study was to report matched clinical outcomes in a large cohort of 930 patients with COVID-19 in the setting of known CD.
Methods:
Analysis of a multicenter research network TriNETX was performed, including COVID-19 patients aged more than 16 years. Outcomes of COVID-19-positive patients with concurrent CD were compared with a propensity-matched cohort of patients without CD.
Results:
A total of 341,499 patients with SARS-CoV-2 infection were identified on the research network: 930 (0.27%) with CD and 340,569 (99.73%) without CD. In the 30- and 60-day periods post SARS-CoV-2 infection, 12 (1.29%) and 13 (1.40%) deaths, respectively, were reported in the CD group. Fewer patients in the CD group reached the composite outcome of either mechanical ventilation or mortality at 60 days (risk ratio 0.58, 95% confidence interval 0.36-0.95). After propensity matching, no difference in clinical outcomes was observed.
Conclusion:
Our data suggest that patients with CD are not at increased risk of COVID-19-related morbidity or mortality.
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