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Solid phase extraction based on trimethylsilyloxy silica aerogel.

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A novel silica aerogel solid-phase extraction method efficiently extracts chemotherapeutic drugs like cyclophosphamide from water. This affordable technique offers comparable or superior performance to commercial cartridges.

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Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Chemotherapeutic drug analysis in water requires efficient extraction methods.
  • Existing solid-phase extraction (SPE) techniques can be complex and costly.

Purpose of the Study:

  • To develop an easy, affordable SPE method for chemotherapeutic drugs using modified silica aerogel.
  • To evaluate the extraction efficiency and performance of the aerogel-based SPE.

Main Methods:

  • Trimethylsilyloxy-modified silica aerogel was synthesized for SPE.
  • Extraction of cyclophosphamide, dexamethasone, and paclitaxel from water was optimized.
  • Method performance was compared against commercial SPE cartridges.

Main Results:

  • The aerogel-based SPE method demonstrated high extraction efficiency for target drugs.
  • Linearity was observed in the range of 4-100 μg L⁻¹, with calculated LOD and LOQ.
  • Aerogel SPE showed comparable or better performance than Oasis HLB, Strata-X-C, C18, and polymeric reversed-phase cartridges.

Conclusions:

  • Modified silica aerogel is a promising, cost-effective material for SPE of chemotherapeutic drugs.
  • The developed method is suitable for analyzing chemotherapeutic drugs in environmental samples like hospital wastewater.